Leah Estrogen

Leah Estrogen is the love interest of Osmosis Jones and the tritagonist of "Osmosis Jones". She is the secretary of Mayor Phlegmming in the City of Frank (a fictional and animated version of the inner human body of live-action character, widowed zookeeper Frank DeTorre), whose skills get her relied on by the Mayor. She's very few of the body's inhabitants who realize the flaws of the current administration, and is willing to believe Osmosis' claims of a large-scale infection. At first, she doesn't like him, but later warms up to him. She is voiced by Brandy Norwood.