Mane Six

The Mane Six, also known as the Elements of Harmony, are the group of six protagonist ponies of My Little Pony: Friendship is Magic. The group, known as the Elements of Harmony or Mane Six, consists of Princess Twilight Sparkle (the main protagonist), Pinkie Pie, Applejack, Rainbow Dash, Rarity, and Fluttershy (the other five protagonists). Besides the Mane Six, Spike is also one of the protagonists, and their good friend, being Twilight's assistant and one of her closest childhood friends. Starlight Glimmer is later added to the main lineup of characters from Season 6 onwards. However, she is not considered a member of the Mane Six.

Trivia

 * The Mane Six is a fan-given name, as the group does not have an official name, but the term has been adopted by the creators of the show. As of 2017, Hasbro has been using the term Mane Six in official descriptions and merchandising. It has not appeared in the show proper, however.
 * "Sonic Rainboom" is the first episode where all of the Mane Six appear without Spike, while The Break Up Breakdown is the first episode where Spike appears without any of the Mane Six.
 * So far, "On Your Marks", "Hard to Say Anything" and "To Change a Changeling" are the only episodes in which all of the Mane Six and Spike are completely absent.