Vanessa Carysle

Vanessa Carlysle is a human who was romantically involved with Wade Wilson/Deadpool.

Born in New Jersey, Vanessa Carlysle had a tough upbringing before becoming a prostitute in New York City. One day, while visiting a bar, she met Wade Wilson and the two eventually began a relationship. A year later, Wade would propose to Vanessa but eventually ended up getting diagnosed with cancer. Desperately trying to save her lover, Vanessa found multiple treatments for Wade. Despite this, the mercenary abandoned her one night and she spent the next few years mourning his loss.

Unknown to her, Wade had actually undergone a procedure that cured his cancer and gave him a healing factor and "super penis". However, the process had disfigured him, causing the mercenary to have a fear of revealing himself to Vanessa. Eventually, the people responsible for Wade's procedure, Ajax and Angel Dust, now mortal enemies with the mercenary, learned of Vanessa's existence and kidnapped her. The two then took Vanessa to a decommissioned aircraft carrier in a scrapyard to kill her in an oxygen deprivation chamber.

Determined to rescue her, Deadpool, alongside X-Men members Colossus and Negasonic Teenage Warhead, confronted Ajax and his subordinates. After defeating his enemies and saving her, Deadpool revealed his new face to Vanessa, who, despite being angry for getting abandoned, accepts him. The two then reconcile and share a kiss.