Annette Birkin was a scientist and wife ofUmbrella Corporation Chief Scientist William Birkin, and the mother of his child - Sherry Birkin. Annette appeared in Resident Evil: The Darkside Chronicles, where she, as opposed to her representation in Resident Evil 2, bears a strong obligation in stopping her mutated husband.
In Resident Evil 2, Annette was a paranoid woman who was obsessed with her husband's research. She protected the G-virus from being stolen by anyone who dared trying to steal it, like Ada. She did come to the realization that she was being a less caring mother to Sherry when she learned that the embryos were soon to hatch inside Sherry's body. She helped Claire to create the vaccine, before she died.
In The Darkside Chronicles however, Annette's personality and motives were altered significantly. Rather than being a paranoid wife obsessed with protecting her husband's research, Annette was portrayed as a very sympathetic and tragic character in that while she allowed her and William's research to take priority over Sherry's welfare she nevertheless loved her daughter deeply and took it upon herself to personally stop the mutated William; even at the cost of her own life.