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Brain is one of the two tritagonists of Igor. He is a robotic brain in a jar who serves as Igor's assistant along with Scamper. Running gag in the film is Scamper always calling him "Brian" because Brain misspelled it with permeating marker. Brain later tapes a piece of paper over the writing with the correct spelling.

He is voiced by Sean Hayes who also voiced Norval the Fish from The Cat in the Hat and Terri Perry from Monsters University.

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