In the game Connors acts as a hero who helps Spider-Man cure most of the cross-species.
Most of his history is the same as his film counterpart but the with the game being in a separate continuity.
After months at Beloit, Spider-Man appeared at the hospital with an odd proposition: Spidey would help Connors escape if Connors helped develop a serum to control the cross-species outbreak and save Gwen Stacy from infection. Connors agreed, sensing an opportunity for redemption. But he made Spider-Man promise not to let the dreaded Lizard resurface.
Spider-Man and Connors worked together to develop the serum. After their first try failed miserably, Spidey questioned Connors' true intentions. Suspicion turned into a tense confrontation, but Connors discovered a startling revelation: Spider-Man was the key to curing the outbreak. Connors used Spider-Man's DNA to create a new, improved serum. For the first time in a while, things were looking up for Curt Connors, but not for long.
Desperation forced him to make a terrible decision: he had no other choice but to transform into the Lizard one final time and use its strength to smash Alistaire Smythe's robot army. As the Lizard, Connors fought as Spider-Man's teammate. But after Smythe's defeat, the Lizard's reptilian brain clawed back in control. However, as a battle for the ages ensued, Spider-Man found the chance to inject the serum into Connors and revert him back to human form.
As promised, Spider-Man returned Connors to Beloit, with a newfound respect for this scientist who helped save Gwen and the people of New York. Today, Connors still wrestles with his inner demons, but his path to redemption has begun.