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Daniel Curien (born 1991) is the tritagonist in The House of the Dead III. He is the son of the infamous Dr. Roy Curien. In fact, he is the primary reason why Curien took part in Goldman's biological science project that soon became responsible for the creation of the undead plaguing the world.

Notorious for his role in the creation of the original undead horde, Dr. Curien's motives are explored through flashbacks. Several years before the Curien Mansion case, in an effort to discover the cure to his son Daniel's terminal illness, he began researching the nature of life and death. Over time however, he became obsessed with his research, as his experiments began taking gruesome and unethical turns. He planned to use it to change the future; this saw the first steps of the great doctor's descent into madness. Living in the shadow of her well-known father, Lisa muses with G about how she is often the subject of comparisons with her father as the two explore the facility, only to come into contact with undead creatures such as EFI's giant one-zombie security force Death, a giant deformed sloth known as The Fool, and a mutant tendril-plant known as The Sun.

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