Domino is one the three tritagonists of Deadpool 2. She is a mutant with powers of luck and probability manipulation.
Domino grew up in the Essex House for Mutant Rehabilitation, and when she left, Domino always knew that he would return one day. Domino joined the new Deadpool band, X-Force. At first Deadpool did not believe that her power - which she described as "lucky" and justifying being in the right place when she had to - was not really power, but she was recruited to the team. Informed of the mission to rescue the young mutant Russell Collins from the prison convoy and protect him from Cable, X-Force planned to save Russel with a parachute jump. In the plane Deadpool was warned of a strong wind that would affect the fall, but they jumped anyway. During the fall, all X-Force members were killed outside of Deadpool and Domino. Domino entered the prison transport and took control over him. Domino managed to keep Cable by the distance until Deadpool arrived. Deadpool and Cable fought for prison transport, but their battle came to an end when Russell released his new friend Juggernaut. Juggernaut caused a prison breakdown and escaped with Russell. Domino was able to land safely in a large inflatable panda in the dealer's driveway. Domino joined forces with Deadpool and Cable to take care of the Juggernaut and stop Russell from killing the Essex House director, who would start him on the path to the darkness that would end with the death of the family Cable'a. While Cable and Deadpool fought Juggernaut, Domino attacked several employees of the orphanage while the building burned around her. Eventually, Juggernaut was defeated when Colossus, Negasonic Teenage Warhead and Yukio from X-Men arrived. Deadpool managed to talk to Russell and prevent the future that led to the death of the Cable family. When the whole team wants to leave runs the director of the orphanage who screams that they are an abomination to God. Then enters Dopinder by killing him. After that, the team quietly leaves.