In 1999, when Ford was a young boy, his mother, Sandra Brody, was killed in the subsequent destruction of the Janjira Nuclear Power Plant leaving only his father Joseph Brody alive.
Fifteen years later, Ford, now a U.S. Navy explosive ordnance disposal officer and father of a family composed of his wife, Elle Brody, and their son, Sam, visited Joe, who convinces him to form a duo to investigate the truth in order to find what caused the incident.
They are quickly arrested by governamental agents and are present when the winged M.U.T.O. awakens and Ford witnessing the death of his father in the chaos. Ford then reveals to Dr. Ishiro Serizawa and Dr. Vivienne Graham (members of the secretive company, Monarch) that his father had monitored echolocation signals that indicated the winged MUTO was communicating with something (who is later revealed to be a female M.U.T.O. whom the winged M.U.T.O., who is in truth a male, intends to mate).
Ford later joins a team delivering many nuclear warheads (who will serve to lure and destroy the monsters) by train, but the female M.U.T.O. intercepts the train and devours most of the warheads and Ford is the only survivor of the attack. He is quickly rescued by many military who has comes to recover the last nuclear wharhead.
As the female and male M.U.T.O. finally met at San Francisco, the female laids thousands of eggs, and used the last nuclear warhead (whom the male had previously stoled from the military) as an energy source for the soon to be offspring, Ford and a bomb disposal squad are then sent in via HALO jump to defuse the bombmen. They removed the nuke, while Godzilla battles the M.U.T.O.s, and Ford also destroyed the eggs.
This inadvertently saved Godzilla (who was overpowered and wounded) as it distracted the M.U.T.O.s who rushed to their nest to find it destroyed, granting Godzilla a reprieve. The female M.U.T.O then noticed Ford and identifying him as the one who destroyed her eggs, attempts to kill him, but Godzilla, having gained his second wind, intervened and returned the favor by incapacitating the female M.U.T.O with his atomic breath twice, knocking her down long enough for Ford to load the bomb onto the boat, and for Godzilla to kill the male before saving Ford's life once again by killing the female with his "kiss of death". With the M.U.T.O.'s EMP ability no longer being in effect, Ford got the boat working, but was too injured to move. Not long afterward, he was saved by a helicopter and was airlifted out as the bomb exploded harmlessly out at sea.
The next day, Ford reunites with his family as they spot Godzilla on the news, seemingly dead from the battle, only to rise up and return to the sea, leaving humanity in peace.