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Isaac is the main protagonist of the game The Binding Of Isaac. He's the son of the christian Mother, who's the main villain of the game appearing as the titular character, he is the most balanced one out of all six in the game. Issac is known for having a rather tough life. He is usually alone, due to him being constantly bullied by other kids.
Issac is a little boy who flees into the basement of his house to escape from a mother who wants to kill him, and must fight for his life against a never-ending assortment of demons and mutants. Beating the game in certain ways or collecting certain items unlocks variations of Isaac with their own unique attributes.
- Isaac, like the game itself is a reference to the story from the bible, known as The Binding of Isaac.