James Evan Wilson was a major character on House from the first season until the end of the series. He was the Head of Oncology at Princeton-Plainsboro Teaching Hospital and also Dr. Gregory House's sole good friend up until his resignation from the hospital and eventual death from Thymoma which he was officially diagnosed with in the Season 8 episode, Body and Soul. Wilson acts as House’s conscience, sounding board, and the enabler of his abusive personality.

He has been married and divorced three times (his first wife was Sam Carr, the second wife was Bonnie Wilson, the third Julie Wilson). He has had an affair with one of his terminally ill patients and dated one of House's rejected applicants, Amber Volakis until her untimely death. Wilson states in Season 1 that he has no children. He does seem to suggest to last girlfriend Sam (also his first wife) that he wants a child with her in Season 7, as when she says she should get a puppy, he replies, "Or pregnant." He proposed to her in the following episode, but it resulted in her leaving him.

He has been treated for clinical depression. Although he cares deeply for House, he often goes behind his back in attempts to help him. For example, although Cuddy proposed the bet to House that he give up Vicodin for a week in order to reduce his clinic duty, it was Wilson's idea. It was also Wilson's idea not to tell House that he was right about Richard McNeil suffering from Addison's disease.

Wilson has gone to extreme lengths to protect and support House, as well as enable House's abusive and manipulative behavior:

  • He was the only board member to vote against firing House in order to satisfy Edward Vogler, which cost him his spot on the board and almost cost him his job.
  • He lied to Michael Tritter when House forged Wilson's signature on Wilson's prescription pad. After Wilson admitted the forgery to Tritter, he once again refused to cooperate with Tritter after House saved yet another patient no-one else could.
  • He was always by House's side when Stacy Warner left him, which eventually cost Wilson his second wife.

He is portrayed by Robert Sean Leonard.

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