KISS are the main protagonists of HB's Scooby-Doo! and Kiss: Rock and Roll Mystery. KISS are a rock band from the planet of KISSteria, which exists in another dimension. And mystery solving superheroes.
The KISS members are decendants of warriors from KISSteria, who locked the Destroyer in a volcano. Like their ancestors, they're sworn to protect the Rock of KISSteria from being found by the Crimson Witch, the Destroyer's creator, and releasing the monster again. They then eventually became the most popular rock band on the planet.
What's New, Scooby-Doo?
The KISS were hired to perform at a costume party in Banning Junction on Halloween Night. When the Ghost of Hank Banning showed up at the party, they indirectly played a vital role by continuing to play and providing inspiring fighting music for the gang.
Scooby-Doo! and KISS: Rock and Roll Mystery
The KISS aid the Mystery Inc fight the Crimson Witch, and solve a mystery that the said villain was really Delilah Domino in disguise. Likewise, they have gained superpowers from the experience.