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The Mane Six, formally known as the Guardians of Friendship, are the main protagonists of My Little Pony: Friendship is Magic and My Little Pony: Pony Life as well as posthumous characters in the 2021 Netflix movie My Little Pony: A New Generation.
The group is comprised of Twilight Sparkle (the leader), Applejack, Rainbow Dash, Rarity, Fluttershy, and Pinkie Pie. Besides the Mane Six, Spike is also one of the protagonists and their good friend, being Twilight's assistant and one of her closest childhood friends. Starlight Glimmer, who used to be one of their worst enemies until Twilight changed her and became one of their closest friends, is later added to the main lineup of characters from Season 6 onward, although she is not an official member of the Mane Six.
The Mane Six is a fan-given name like the group does not have an official name until the release of My Little Pony: Make Your Mark where they were collectively known as the "Guardians of Friendship", but the term has been adopted by the creators of the show. As of 2017, Hasbro has been using the term Mane Six in official descriptions and merchandising. It has not appeared in the show proper, however.
None of the Mane Six appear in the following episodes: On Your Marks, Hard to Say Anything, To Change a Changeling, Marks and Recreation, The Break Up Break Down, Frenemies, and Student Counsel.