Hero Overview

You dealin' with a white blood cell here!
~ Osmosis Jones
You want Osmosis? You got Osmosis!
~ Ozzy's catchphrase

Osmosis "Ozzy" Jones is the titular main protagonist of the 2001 film of the same name and its spin-off TV series Ozzy & Drix.

Despite being a police officer, he doesn't seem to have much respect for authority. His best friend's Drix and he has a crush on the mayor's secretary Leah Estrogen. He is funny and adventure-seeking. Ozzy will anything to keep Frank in shape, even if it means stopping Thrax.

He was voiced by Chris Rock in the film, who later voiced Marty and was voiced by Phil LaMarr in the TV series who also voices Marty in the Madagascar video games, Samurai Jack, Static, Wilt, and Green Lantern.


Ozzy's a baby-blue white blood cell. He wears a white t-shirt with a brown jacket, black pants, and black shoes.


Ozzy's an adventurous, resourceful, rebellious, carefree, inept, and funny white-blood cell who tries to keep Frank DeTorre healthy.

When he sees Leah, he gets all flirty and tries to impress her. Ozzy can be very kind to his friends and he always knows what's right. Ozzy's also very brave when confronts Thrax two times.


Ozzy's first seen when the movie enters into Frank's body for the first time. He's seen on Mouth Patrol in a helicopter reading a magazine called DNA which is a knock off of Playboy magazines.

Soon while in the helicopter the pilot spots a group of germs that they believed that were Gingivitis manage to hijack a squad car and were chased and shot at by Ozzy but were sucked into Frank's windpipe by a yawn.

Then Ozzy jumps out of the helicopter to go after the germs, but he only manages to get the smallest out of group. Despite being told to stay out of the chase, Ozzy follows the germs and accidentally triggers a cramp in Frank's right leg.

Back in the mouth, some spit cells are still breaking down the egg when a Virus named Thrax appears and after burning the spit cells and their boat, triggers a sore throat.

Then Ozzy's chewed out by the Chief for his earlier violation of orders. Then the Chief assigns Ozzy to investigate the throat on the condition that he works with a cold pill named Drix.

At the throat, Ozzy encounters a Spanish Germ who saw Thrax's earlier attack and he refers to him as "The Red Death" before being accidentally frozen by Drix.

Then Ozzy and Drix head to the nose where, after Frank sneezes, Thrax and the germs create a stuffy nose to make it seem like Frank's condition's the common cold.

Back at Mayor Phlegmming's office, Ozzy tries to inform him that a virus is in the body, but then he's threatened to be sent down the next nose bleed if he can't keep quiet. Mayor Phlegmming offers to reassign Drix to another partner, but Drix decides to stay with Ozzy.

While heading to the liver, Drix asks Ozzy why Mayor Phlegmming said Ozzy had a record. Ozzy explains that two years ago, Frank was at the science fair of Shane's school and ate some potentially rotten Oysters off a random kid's science project.

When Ozzy was in the stomach he saw some threatening bacteria coming from the Oysters, including a nasty-looking virus. Believing he had no time to call for backup or ask questions, Ozzy hit the "puke" button, causing Frank to throw up all over Miss Boyd, one of Shane's teachers. As a result of this, while Frank's life was saved by the bacteria being forcibly expelled from his body in this way, Frank lost his job at a pea soup factory, and then he became the town's laughing stock, Then Mrs. Boyd issued a 200-yard restraining order and then Ozzy got suspended for what he felt to the mayor like "unnecessary force" and then he placed him on out-of-the-way patrols ever since. Then he wonders if he did the right thing since that day.

Then Drix says that he feels Ozzy was justified in his decision cause Oysters are a known as a breeding ground for any number of dangerous bacteria, to which Ozzy stated that they are, and he never thought that Drix would stood up to him, to which Drix never thought he'd be right.

At the liver, a Flu Shot informs them that Thrax's big time and that he's currently in The Zit club, a hangout for all the germs in the body. Once there, Ozzy disguises himself as a germ and then he discovers that Thrax plans to invade the Hypothalamus and heat up Frank's body, killing him in 48 hours and getting him a chapter in medical books, since each of his previous victims have died faster than the last.

Then Ozzy's exposed and a fight breaks out. Drix tries loading a freezing grenade into his arm, but it gets stuck, so Ozzy takes it and throws it at Thrax, causing The Zit club to explode off of Frank's forehead.

Meanwhile, Frank's trying to get Miss Boyd to lift a restraining order so he can join Shane on a dad and daughter hike, but the Zit club pops onto her bottom lip, making her refusseal official.

When Ozzy returns to the Third Precinct, Mayor Phegmming berates him for popping The Zit club without an official permit. Then Ozzy and Drix tell him that if they hadn't done it, Frank's whole body would be destroyed. Mayor Phlegmming tells Ozzy to be careful of what he says as that kind of talk would cause a panic (in addition to reducing his chances of not getting re-elected). When Ozzy argues that it would make the citizens think more about the body's health than the chicken wing trip to Buffalo, then Mayor Phlegmming angrily fires him.

When Drix defends Ozzy by saying Frank would've been in mortal danger if not for Ozzy's intervention, Mayor Phlegmming tells him to leave the body since his abilities are temporary and therefore keep him from proving the truth.

What they didn't know, was that Thrax survived the explosion and after killing off his remaining henchmen for suggesting that they incubate, he decides to launch a lone assault on the Hypothalamus by disabling its self-regulative capabilities.

Arriving there, Thrax uses his long claw on his left hand to destroy the protoplasmic barrier around the gland and retrieve a DNA bead, causing the body to slowly start overheating.

Soon after, Leah Estrogen, the mayor's secretary and Ozzy's love interest, discovers his work and alerts security.

Thrax manages to evade them, taking Leah hostage and escapes from the brain to the mouth.

At the same time, Ozzy, in a movie theater showing dreams from the brain, discovers that Thrax's alive in the brain when the movie screen turns a feverish red and the dream becomes a nightmare.

Then Ozzy rushes to stop Drix from leaving the body and then he manages to convince him to help stop Thrax once and for all. Meanwhile, Frank's temperature continues to rise, causing chaos and destruction to break out all over the City of Frank.

Then Frank's taken to the hospital under the influence of Thrax's attack. Then Ozzy and Drix rescue Leah and confront Thrax, who leaves Frank's mouth after causing Frank to sneeze using pollen pods.

Then Ozzy's launched out after him by Drix where Ozzy and Thrax fight on Shane's eye and then they end up on Shane's false eyelash after she blinks which she was wearing atop her natural ones. During the fight, Thrax threatens to break his own record by killing Shane, but Ozzy tricks him into getting stuck on Shane's false eyelash, and fall into a beaker of rubbing alcohol below where he dissolves to death.

During this time, the situation becomes even more dangerous when the temperature hits 108 degrees, causing Frank to get Hyperpyrexia.

Just as the doctors are prepared to give up, Frank's revived when Ozzy returns to Frank on one of Shane's tears with the DNA chain containing the missing Hypothalamus chromosome.

Then Ozzy's reinstated into "Immunity" with full privileges, and Ozzy and Drix are declared heroes with the Chief of Police giving Ozzy his job back, Ozzy, planning on extending Drix's time in Frank with help from the hemorrhoid, and Leah returns his affections.

Powers and Abilities

Being a white blood cell, Ozzy's pliable and he has elasticity, he can stretch all his limbs and body and he has shape-shifting abilities.


  • Ozzy was disliked by everyone in the beginning, but was treated better after saving the day.
  • He and Drix are the main characters in the tv show, "Ozzy and Drix." Who's the private-eye investigator in the City of Hector (a fictionalized version of the human body of an animated Cuban-American teenager named Hector Cruz.) and he's voiced by Phil LaMarr in its spin-off TV series.
  • Ozzy's relationship with Drix's similar to Carter's relationship with Lee from the Rush Hour films.
  • Anthony Anderson, D.L. Hughley, Matthew Broderick, Alex Winter, Cuba Gooding Jr., Harry Enfield, Woody Harrelson, Chris Tucker, Chris O'Donnell, Todd Stashwick and Martin Short were considered for the role of Osmosis Jones.
  • Will Smith was interested in the role of Ozzy, but was unable to do the part due to scheduling conflicts.
  • Chris Rock's first time voice acting in a theatrically released animated film. Later he'd go onto voice Marty the Zebra in the Madagascar films and Mooseblood the Mosquito in Bee Movie (2007).


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