The Savior Group attempts to protect Japan from the growing threats of the bestial Ruffians and the ruthless Armed Volunteers. Joined by Saki's love interest and future wife, Airan. Following a purge, Saki, Airan, and Achi are the only survivors, and attempt to reach a transport to leave the city.
Saki transforms into a giant Ruffian after falling into a rising tide of blood during a fight with a telekenetic woman named Kachua. He then battles her and destroys her in Ruffian form but then turns on Airan and Achi. Achi teleports Airan and herself to safety, while Saki marches onward to the Ruffian hive.
Saki is saved from the Armed Volunteers by Airan and Achi and returned back to human form when Airan is physically placed into his body, reminding him of what it means to be human.
Towards the end of the game, Airan is kidnapped by Achi, who reveals that Saki was being groomed as a leader in a much larger conflict involving cosmic powers. Saki defeats Achi and is reunited with Airan. With Japan in ruins, the two wonder about their future.
At some point, he and Airan have a son named Isa. The ultimate fate of Saki and Airan is not touched upon in the sequel.