In the beginning of the movie Hotep and Huy offer her to Rameses as a concubine at a banquet. Ramses gives her to his adoptive brother Moses after she nearly bites him. Moses ends up sending Tzipporah into a pond, to which she gives him an angry glare before Ramses has servants take her away to be dried and sent to Moses' room. However, Tzipporah ties up the man charged with escorting her to Moses' room and escapes. She is then offered water by Miriam (who is Moses' biological sister) before returning to he home.
After learning his true Hebrew origins and accidentally causing the death of an Egyptian guard, Moses exiles himself from Egypt ad crosses many miles of desert, and eventually reaches the land of the Midians, Tzipporah's people, who worship the Hebrews' god. After Moses saves Tzipporah's sisters from bandits, he is welcomed warmly into the tribe by their father Jethro, the High Priest. After assimilating in this new culture, Moses becomes a shepherd and gradually earns Tzipporah's respect and love, culminating in their marriage.
Sometime later, Moses is is called upon by God to return to Egypt and free the Hebrew slaves there. Tzipporah accompanies Moses back to Egypt where he tries to convince Ramses (who is now Pharaoh) to free the Hebrews, only for Ramses to refuse and double the Hebrews workload. Tzipporah later comes to Moses' defence when his biological brother Aaron calls him out for not caring about the Hebrews until he found out he was one.
Tzipporah and Moses both express sadness during the tenth plague, where the Angel Of Death kills the first born children of Egypt.
At the end of the film, after the Hebrews escape Egypt, Tzipporah tells Moses "Look. Look at your people, Moses. They are free".