This is Margo Gru the Eldest orphaned girl and the adoptive Daughter of Gru.
And these are the heroines who are similar to her.
Jeanette Miller (Alvin and the Chipmunks series)
Velma Dinkley (Scooby-Doo series)
Twilight Sparkle (My little Pony: Friendship is Magic)
Dorothy Gale (The Wizard of Oz)
Lisa Simpson (The Simpsons)
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Lady Sun (Romance of the Three Kingdoms)
Oichi (Samurai Warriors series)
Skipper Roberts (Barbie series)
Blossom (The PowerPuff Girls)
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Pastel (TwinBee series)
Amy Rose (Sonic the Hedgehog series)
Jenny Foxworth (Disney's Oliver and Company)
Betty Cooper (Archie series)
Wendy the Good Little Witch (Casper the Friendly Ghost)
Karen (Frosty the Snowman)
Kim Possible
Penny Sanchez (ChalkZone)
Sam Sparks (Cloudy with a Chance of Meatballs series)
Yuri Sakazaki (Art of Fighting and The King of Fighters series)
Emi (Dance Dance Revolution series)
Vanellope Von Schweetz (Disney's Wreck-It Ralph series)
Mavis Dracula (Hotel Transylvania series)
Shizuka Minamoto (Doraemon series)
Penny (Disney's Bolt)
Keira Hagai’s (Jak and Daxter series)
Gwen Tennyson (Ben 10 original series)
April O'Neil (TMMT 2012)
Tea Gardner (Yu-Gi-Oh!)
Misako (Kunio-kun series)
Roll Caskett (Mega Man Legends series)
Mary Jane Watson (Sam Raimi's Spider-Man Trilogy)
Cindy Lou-Who (Dr. Seuss' How the Grinch stole Christmas)